COO
Margaret (Peg) A. Horn, J.D., 62, is the Chief Operating Officer at Revolution Medicines, Inc. (RVMD), a clinical-stage biopharmaceutical company developing targeted therapies for RAS-addicted cancers, since October 2018.[[1]](https://fintool.com/app/research/companies/RVMD/people/margaret-horn)[[2]](https://www.sangamo.com/board-of-directors/margaret-peg-a-horn-j-d/)[[6]](https://www.revmed.com/team/margaret-peg-horn-j-d/) She previously served as Executive Vice President and General Counsel at Revolution Medicines from December 2014 to October 2018, and oversees corporate development, investor relations, legal, information sciences, and facilities.[[1]](https://fintool.com/app/research/companies/RVMD/people/margaret-horn)[[2]](https://www.sangamo.com/board-of-directors/margaret-peg-a-horn-j-d/)[[6]](https://www.revmed.com/team/margaret-peg-horn-j-d/) Horn recently sold 75,000 shares of RVMD stock on January 7, 2026, at $100.56 per share, reducing her beneficial ownership to 141,053 shares valued at approximately $14.18 million.[[3]](https://www.marketbeat.com/instant-alerts/margaret-horn-sells-75000-shares-of-revolution-medicines-nasdaqrvmd-stock-2026-01-09/)
Horn brings over 30 years of biotechnology leadership experience, with prior roles including Chief Operating Officer at ProLynx LLC (2010–2014), Senior Vice President of Legal and Corporate Development at Kosan Biosciences, Inc., and Senior Vice President of Legal at Genencor International, Inc.[[1]](https://fintool.com/app/research/companies/RVMD/people/margaret-horn)[[2]](https://www.sangamo.com/board-of-directors/margaret-peg-a-horn-j-d/) She has led strategic transactions such as R&D collaborations, commercialization agreements, licenses, M&A, and equity financings.[[2]](https://www.sangamo.com/board-of-directors/margaret-peg-a-horn-j-d/) Horn holds a B.S. in Pharmacy from the University of the Sciences in Philadelphia, a J.D. from Villanova University, and an executive MBA from Penn State.[[1]](https://fintool.com/app/research/companies/RVMD/people/margaret-horn) Since December 2022, she has served as a director at Sangamo Therapeutics, Inc.[[1]](https://fintool.com/app/research/companies/RVMD/people/margaret-horn)[[2]](https://www.sangamo.com/board-of-directors/margaret-peg-a-horn-j-d/)
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