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SYRE - Spyre Therapeutics, Inc.

Insider Sale by Burrows Scott L (CFO)

1 Month
After Trade
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Trade Summary

4 days ago, Burrows Scott L, serving as CFO at Spyre Therapeutics, Inc. (SYRE), sold 12,500 shares at $71.37 per share, for a total transaction value of $892,125.00. Following this transaction, Burrows Scott L now holds 97,994 shares of SYRE.

This sale represents a 11.00% decrease in Burrows Scott L's stake in the company. This is considered a high-conviction trade given the significant change in ownership.

The trade was executed on Friday, May 1, 2026 and publicly disclosed via SEC Form 4 filing on Friday, May 1, 2026, meaning the disclosure happened on the same day as the trade.

Spyre Therapeutics, Inc. operates in the HEALTHCARE sector, specifically within the BIOTECHNOLOGY industry. Insider selling activity in this sector can provide valuable signals about industry trends and company-specific developments.

Burrows Scott L

CFO

Scott L. Burrows is the Chief Financial Officer of Spyre Therapeutics, Inc. (NASDAQ: SYRE), a biotechnology company focused on developing therapies for immune-mediated diseases, a role he has held since September 1, 2023.[[1]](https://fintool.com/app/research/companies/SYRE/people/scott-burrows)[[6]](https://www.spyre.com/people/scott-burrows) At 48 years old, Burrows brings over two decades of biopharma finance experience, including prior positions as CFO (2021–2023) and VP of Finance (2019–2021) at Arcutis Biotherapeutics, where he led the IPO and financings; Head of International Investor Relations at Shire (2018–2019) during its Takeda acquisition; and 15 years at Amgen in FP&A, treasury, and investor relations.[[1]](https://fintool.com/app/research/companies/SYRE/people/scott-burrows) Burrows holds a B.A. and M.B.A. from UCLA and is a licensed CPA (inactive).[[1]](https://fintool.com/app/research/companies/SYRE/people/scott-burrows) As CFO, he has overseen financial stewardship during Spyre's growth from a market cap under $50 million pre-merger to over $1 billion by end-2023, including signing key earnings releases and managing compensation tied to clinical milestones like SPY001/SPY002 advancements.[[1]](https://fintool.com/app/research/companies/SYRE/people/scott-burrows) Recent insider trades include selling 18,428 shares on September 2, 2025, for tax obligations on RSUs, and 2,500 shares on March 3, 2026, under a Rule 10b5-1 plan after exercising options, retaining 97,994 shares.[[2]](https://www.investing.com/news/insider-trading-news/burrows-spyre-therapeutics-cfo-sells-299k-in-shares-93CH-4223165)[[3]](https://www.stocktitan.net/sec-filings/SYRE/form-4-spyre-therapeutics-inc-insider-trading-activity-6045edd82436.html)[[4]](https://www.marketbeat.com/instant-alerts/scott-burrows-sells-2500-shares-of-spyre-therapeutics-nasdaqsyre-stock-2026-03-03/)

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Trade Price

$71.37

Quantity

12,500

Total Value

$892,125.00

Shares Owned

97,994

Trade Date

Friday, May 1, 2026

4 days ago

SEC Filing Date

Friday, May 1, 2026

HEALTHCAREBIOTECHNOLOGY

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