Trade Summary

4 days ago, HENDERSON MICHAEL THOMAS, serving as Dir at Spyre Therapeutics, Inc. (SYRE), sold 20,000 shares at $100.00 per share, for a total transaction value of $2,000,000.00. Following this transaction, HENDERSON MICHAEL THOMAS now holds 68,606 shares of SYRE.

This sale represents a 22.57% decrease in HENDERSON MICHAEL THOMAS's stake in the company. This is considered a high-conviction trade given the significant change in ownership.

The trade was executed on Monday, June 22, 2026 and publicly disclosed via SEC Form 4 filing on Wednesday, June 24, 2026 (accepted Jun 23, 9:32 PM ET), 2 days after the trade was made.

Spyre Therapeutics, Inc. operates in the HEALTHCARE sector, specifically within the BIOTECHNOLOGY industry. Insider selling activity in this sector can provide valuable signals about industry trends and company-specific developments.